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穆赫塔尔.伊米尔艾山 副教授 、硕士生导师
2017-03-20 17:51   审核人:

         名:穆赫塔尔伊米尔艾山

                   Mukhtar  Imerhasan

职称/职务: 副教授、硕士生导师

        业:有机化学

研究方向  1. 功能螺-稠杂环药用分子设计、合成及构效关系研究

2.  保健食品功效成分、性能及配方优化研究

出生年月:  17 NOV 1962

 

 

 

 

 

 

 

 

 

 

联系方式:

   箱:imerhasan@xju.edu.cn     imerhasan@yahoo.com

办公室:0991-8582654

  话:13999251745

个人经历:

教育经历

1981/09 – 1986/07,新疆大学,化学系,学士

1991/09 – 1993/06,新疆大学,政治系,法学双学士

1999/02 – 2000/01,同济大学,留德预备部,学德语

2002/02 – 2002/07,北京语言文化大学,德语系,德语强化

2002/10 – 2003/10,德国斯图加特大学,化学系做访问学者

2014/12 – 2015/12,德国霍恩海姆大学,化学系做访问学者

工作经历

1986/07 – 1993/09,新疆大学,化学系,助教

1993/09 – 2005/09,新疆大学,化学化工学院,讲师

2005/09 – 至今, 新疆大学,化学化工学院,副教授

国家级项目:

主持项目:

 新型含羟基内酯环的双螺杂-N-甲基异噁唑烷类化合物的合成及构效关系研究,国家自然科学资金(21062019),总6人, 排名第一,201101月至201112, 资助金额:12.0万,

  9-吖啶取代异噁唑为核心环的稠杂环类化合物的合成及构效关系研究,  新疆维吾尔自治区自然科学基金项目(编号为 200421126,  200401-200712,  资助金额:7.0万元

  蕈毒碱类抗白粉病药物分子的设计、合成及药物活性筛选,国家自然科学资金(编号为21462043),总6,项目起止:201501月至201812月,资助金额:53.00万元,

其它项目:

2)参与项目:

 用活性引发剂制备纳米印迹聚合物及其在荧光免疫分析中的应用,国家自然科学资金(21065011),总6,排名第二,201101月至201312,   资助金额:25万,

  新疆紫草抗肿瘤成分的提取,结构改造及活性的研究,国家自然科学基金(30069004),9,排名第二,20011月至200412,  资助金额:20万,

 分子印迹在线富集与光纤传感用于抗HIV药物监测的研究,自治区教育厅高校青年教师科研启动基金(XJEDU2007S05),4,排名第二,资助金额:8

《杂环化合物的共振能和稳定性的研究》, 校管科研课题项目,1997

代表性研究成果:

发表文章:

40.   L. Maihesutia,b, L. Pan,  M. Imerhasan*,  Komila. A. Eshbakova, X.G. Jia, A new spiro Compound from Caragana Acanthophylla. Chemistry of Natural Compounds.

力瓦衣丁买合苏提,潘兰,穆赫塔尔伊米尔艾山*Komila. A. Eshbakova. 贾晓光,从刺叶锦鸡儿(Caragana Acanthophylla)中分离的新螺环化合物,天然产物化学,

39.  Imerhasan, Mukhtar*  Helil, Setiwaldi   Mahmud, Muhammed Amin Synthesis and in vitro Anticancer Activity of N-methylisoxazolinium-salts with Carboxyl or Estergroups against Cell Division Cycle 25B Phosphatase and Protein Tyrosine Phosphatase-1Chin. J. Org. Chem.,2017,37(3):496-502.

穆赫塔尔伊米尔艾山* 萨提瓦力迪海力力  麦麦提依明马合木提.含羧基或酯基的N-甲基异噁唑啉盐的合成及其对细胞分裂周期25B酸酯酶和蛋白酪氨酸磷酸酶-1的体外抗癌活性, 有机化学,2017,37(3):496-502.

38. G. Haydar ,M. Imerhasan* , K.A.Eshbakova, Kurbanbaeva A.E. Synthesis and in vitro anticancer activity of    natural product analogs on the based on the acridine skeleton 1,2,4-oxadiazoline and pyrazoline derivatives against Cdc25B[J].Journal of Pharmaceutical and Biological Sciences, 2016; 4(2): 41-45  Published: 03-03-2016

基于吖啶骨架的1,2,4-恶二唑啉和吡唑啉天然产物类似物的合成及其对CDC25B的体外抗癌活性. Pharmaceutical and Biological Sciences,2016; 4(2): 41-45论文编号

37. Mukhtar Imerhasan*, Gulbostan Hayder, Ghayret SultanSetiwaldi Heli,Muhammed A. Mahmud. Synthesis and in Vitro inhibitory activity of 1,2,4-oxadiazoline and pyrazoline derivatives containing acridinyl against Cdc25B[C], Abstracts, the 11thInternational Symposium on the Chemistry of Natural Compounds (SCNC 2015) on October 01-04, 2015 in Antalya, Turkey

36. Imerhasan, Mukhtar*; Helil, Setiwaldi; Sultan, Ghayret. Synthesis and Bioactivity of Ethylcarboxy Dioxypyrrolino[3',4'-d]-N-methylisoxazolinium-tetrachloroferrate Derivatives[C], Abstracts, the th International Conference Technical Chemistry: Theory to praxis, October 21-23, 2014, Perm, Russia Federation.

35.  Mukhtar Imerhasan*, Kurban Osman , Setiwaldi HelilGhayret Sultan. Study on Nutritional Components of the Uyghur Traditional Food-acid curd and Effects on Anti-oxidation, china dairy industry 2014,42(10):7-10.穆赫塔尔·伊米尔艾山*, 库尔班·吾斯曼, 萨提瓦力迪·海力力, 艾来提·苏里坦, 维吾尔传统奶制品酸凝乳的营养成分和抗氧化性能的研究, 中国乳品工业杂志, 2014,42(10):7-10.

34. M. Imerhasan, A. Sultan, Y. Turahun, S. Helil, M. A. Mahmud, L. Mahsud. Synthesis and Anticancer Activity of Monocyclic β-Lactams and 4-Thiazolidinones Derivatives Containing Acridinyl[C], Abstracts, Xth International Symposium on the Chemistry of Natural Compounds, November 21-23, 2013, Tashkent Uzbekistan: 218.

33. A. Sultan, M. Imerhasan, Y. Turahun, S. Helil, R. Niyaz. Study on Chemical Constituents and Extraction Technique of Salx caprea of Xinjiang[C], Abstracts,Xth International Symposium on the Chemistry of Natural Compounds, November 21-23, 2013, Tashkent Uzbekistan: 220.

32. Liwayidin Mahsud, Mukhtar Imerhasan, Muhammad Amin Mahmud,  Setiwaldi Helil,Liu Huajun. Synthesis and Bioactivity of Monocyclic β-Lactams and 4-Thiazolidinones Derivatives Containing Acridinyl, Chinese Journal of Organic Chemistry, 2014,34(6):1235-1239.

力瓦依丁·买合苏提,穆赫塔尔·伊米尔艾山* ,麦麦提艾力·奥布力,萨提瓦力迪·海力力, 刘华君.含吖啶基的单环β-内酰胺及噻唑啉酮衍生物的合成及其生物活性,  有机化学,2014,34(6):1235 -1239.

31. Mukhtar Imerhasan*Gulbostan HaydarKurban Osman. Study on Nutritional Components of the white Cornmeal and its Anti-oxidation activity [J], Hans Journal of Food and Nutrition Science, 2012, 1 (11):34-41.

穆赫塔尔·伊米尔艾山*,  古丽伯斯坦·阿依达尔, 库尔班·吾斯曼,白玉米粉的营养成分和抗氧化性能的研究[J], 食品与营养科学,2012, 1 (11):34-41.

30. Abdukerem Abdureyim, Mukhtar Imerhasan*, Setiwaldi Helil. Study the oxidation resistance of Hotan (Mulberry) paper-Uyghur traditional handcrafts [J], Natural Product Research and Development, 2012, 24(11):1637-1641.

阿不都克热木·阿不都热依木,穆赫塔尔·伊米尔艾山* 萨提瓦力地·赫力力.维吾尔传统手工艺品和田纸的抗氧化性能研究[J], 天然产物研究与开发, 2012, 24(11): 1637-1641.

29. Ali, Turmuhammad  Imerhasan, Mukhtar*  Hudabergen, Aynur. Synthesis and Bioactivity of Novel Dioxy-pyrrolino[3,4-d] N-Methylisoxazolinium-tetrachloroferrate Derivatives[J], Chinese Journal of Organic Chemistry, 2012,32(2):376-381

图尔麦麦提·艾力,穆赫塔尔·伊米尔艾*,阿依努尔·胡达依别尔根.新型二氧代氮杂茂并[3,4-d]N-甲基异噁唑四氯化铁酸盐衍生物的合成及其生物活性[J],有机化学,2012,32(2):376-381.

28.  Yunusjan Turahun,  Mukhtar Imerhasan, Found in the history of the chemical substance is the center of the present invention[J], Journal of Chemical Education, 2012,33(1):78-80.

尤努斯江·吐拉洪, 穆赫塔尔·伊米尔艾山, 化学物质为中心的发明发现的历史[J], 化学教育,2012,33(1):78-80.

27. Mukhtar Imerhasan*, Setiwaldi HelilKurban OsmanTurghun Muhammad. Study on Nutritional Components of the white Cornmeal and its Anti-oxidation activity[C], Abstracts,    9thInternational Symposium on the Chemistry of Natural Compounds, October 16-19,2011, Urumqi Xinjiang China: 84.

26.  Aynur Hudabergen,  Abdukaiyum Abdurashid Mukhtar Imerhasan*, Turmuhammad Ali. Inhibitory activity of dioxy-pyrrolino [3', 4'-d]isoxazoline derivatives containing (1', 2'-O-cyclohexylidendioxyethyl) against Cdc25A and CD45[J], Acta Pharmaceutica Sinica,  2011, 46 (10): 1209-1214    

阿依努尔·胡达依别尔根,阿布都克尤木阿布都热西提,穆赫塔尔·伊米尔艾山*,图尔麦麦提·艾力.(1,2--O-环亚己基二氧乙基)的二氧代氮杂茂并[3,4-d]异噁唑啉衍生物对Cdc25ACD45的抑制作用[J],药学学报, 2011,46(10):1209-1214.

25. Nurmemet Hudaberdi, Turghun Muhammad, Mukhtar Imerhasan. Synthesis of N-[2-(diethylamino)ethyl]-2′,6′-Xylidine derivatives and study on their fluorescence properties[J], Chinese Journal of Chemical Research and Application, 2011,23(2):239-243.

24. 努尔买买提库达巴尔地,吐尔洪·买买提*, 穆赫塔尔·伊米尔艾山N′-芳基-N, N-二乙基乙二胺衍生物的合成及荧光性质研究[J],化学研究与应用,2011,23(2):239-243.

23. Imerhasan, Mukhtar*;  Wang, Ting; Helil, Setiwaldi; Osman, Kurban; Muhammad, Turghun, Synthesis and Bioactivity of Novel Pyrrolino[3′,4′-d]isoxazole Derivatives Containing Acridinyl[J], Chinese Journal of Organic Chemistry,2010,30(12):1884-1889.

穆赫塔尔·伊米尔艾山* , 王婷, 萨提瓦力迪·海力力, 库尔班·吾斯曼, 吐尔洪·买买提,含吖啶基的新型二氧代氮杂茂并[3′,4′-d]异噁唑衍生物的合成及其生物活性研究[J],有机化学,2010,30(12):1884-1889.  

22. Wang, Ting;  Imerhasan, Mukhtar* . Synthesis and Application of Isoxazolinium Salts[J], Chinese Journal of Organic Chemistry, 2010,30(12):1831-1839.

王婷, 穆赫塔尔伊米尔艾山* . 异噁唑啉盐的合成及其应用[J],有机化学, 2010,30(12):1831-1839.    

21.  Volker Jäger, Wolfgang Frey, Yaser Bathich, Sunitha Shiva, Mohammad Ibrahim, Marco Henneböhle, Pierre-Yves Le Roy,  Mukhtar Imerhasan.  2-Isoxazolinium Salts and 3-Isoxazolines: Exploratory Chemistry and Uses for the Synthesis of Branched Amino Polyols and Amino Acids[J],  Z. Naturforsch. 2010,65b, 821-832.

探索2-异噁唑啉盐和3-异噁唑啉在氨基多醇和氨基酸分枝合成中的应用

20. Mukhtar Imerhasan, Kurban Osman, Setiwaldi Helil, Turghun Muhammad. Study on Nutritional Components of the Uyghur Traditional Food-Agastache rugosus jam and Its Anti-oxidation Activity[J], Food and Fermentation Industries, 2010,36(4):45-49.

穆赫塔尔伊米尔艾山,库尔班吾斯曼,萨提瓦力迪海力力,吐尔洪买买提.维吾尔传统藿香果酱的营养成分和抗氧化性能[J],食品与发酵工业,2010,36(4):45-49.  

19. Kurban Osman , Alimjan Mejit, Mukhtar Imerhasan, Rukiya Sawut, Patigul Imerhasan. Reform in Teaching Organic Chemistry with the “113” Teaching Model[J],Higher Education of Sciences, 2009,17(2): 118-120

库尔班吾斯曼,阿力木江米吉提,穆赫塔尔伊米尔艾山,茹克亚沙吾提,帕提古丽伊米尔艾山. “113”培养模式下的有机化学教学内容与实践改革的思考[J]. 高等理科教育2009,17(2): 118-120   出版号:ISSN 1000-4076   CN 62-1028/G4

18. Kurban Osman, Mukhtar Imerhasan, Patigul Imerhasan.  Extraction and Bacteriostatic Activities of Polysaccharide in Seed of Portulaca Oleracea L. [J], Food Research and Development,2009,30(7): 28-30

库尔班吾斯曼,穆赫塔尔伊米尔艾山,帕提古丽伊米尔艾山.马齿苋子中多糖的提取分离及抑菌活性研究[J]. 食品研究与开发,2009,30(7):28-30

17. Mukhtar IMERHASAN* , Kurban Osman, Patigul Imerhasan. Exploring and Practice Extracurricular Research Practice Training Improve Ethnic Group Students Comprehensive Quality[J], Journal of Xinjiang University, 2009,37(1, 增刊): 53-54

穆赫塔尔·伊米尔艾山* ,库尔班·吾斯曼,帕提古丽·伊米尔艾山. 课外科研实践训练中提高少数民族学生综合素质的探索与实践[J]. 新疆大学学报,2009,37(1, 增刊): 53-54

16. Gheni Kurban, Mukhtar Imerhasan*, Kurban Osman, Setiwaldi Helil ,Xarapat Tursun. Determination of contents of nutrition and microelement in the Uyghur Traditional health protection medicinal materials Herba Cistanches[J], Science and Technology of Food Industry, 2009,30(9):289-291

艾尼库尔班,穆赫塔尔伊米尔艾山*,库尔班吾斯曼,萨提瓦力地赫力力,夏热帕提吐尔孙.维吾尔传统保健药材肉苁蓉中营养成分、微量元素含量的测定[J]. 食品工业科技,2009,30(9):289-291   出版号:ISSN 1002-0306   CN 11-1759/TS

15. Abdukeyum Abdurexit, Mukhtar Imerhasan, Kurban Osman, Wang Ting. Synthesis of Containing (1′,2′-O-Cyclohexylidendioxyethyl) of Novel pyrrolino[3′,4′-d]isoxazole Derivatives[J],Chinese Journal of   Synthetic Chemistry2009,17(3): 337-341

阿布都克尤木阿布都热西提, 穆赫塔尔·伊米尔艾山*, 库尔班·吾斯曼,王婷. (1,2--O-环己叉二氧乙基)的新型二氧代氮杂茂并[3,4-d]异噁唑衍生物的合成[J], 合成化学,2009,17(3): 337-341  出版号:ISSN 1005-1511   CN 51-1427/O 6

14. Proceeding of 1 th International Symposium on Edible Plant Resources and the Bioactive Ingredients[C], july 23-25,2008, Urumqi Xinjiang China: 41-46

穆赫塔尔伊米尔艾山,艾来提苏力坦,萨提瓦力地,吐尔洪,维吾尔传统保健饮料药桑椹原果汁中总黄酮、营养素和微量元素含量的测定[C],第一届可食植物资源及活性成分国际学术研讨会,2008723-25日,乌鲁木齐,中国新疆:41-46

13.Mukhtar Imerhasan, Kurban Osman,Turghun Muhammad, Setiwaldi Helil, Gulbostan Haydar,Synthesis and Bioactivity of Containing Carboxyl-and Estergroups of Novel Pyrrolino[3,4-d]isoxazole Derivatives[J], Chinese Journal of Applied Chemistry,2008,25(8):931-936

穆赫塔尔·伊米尔艾山,库尔班·吾斯曼,吐尔洪·买买提,萨提瓦尔迪·海力力,古丽伯斯坦·阿依达尔,含羧基或酯基的新型二氧代氮杂茂并[3′,4′-d]异噁唑衍生物的合成及其生物活性研究[J],应用化学,2008,25(8):931-936   出版号:ISSN1000-0518   CN 22-1128/O6

12. Mukhtar Imerhasan, Kurban Osman,Turghun Muhammad, Setiwaldi Helil, Gulbostan Haydar,Determination of total flavonoid, alkaloid and nutrition in the Uyghur Traditional Food-rose Jam[J], Food and Fermentation Industries,2008,34(3):153-156.

穆赫塔尔伊米尔艾山,库尔班吾斯曼,吐尔洪买买提, 萨提瓦尔迪海力力,古丽伯斯坦阿依达尔,维吾尔传统玫瑰花果酱中总黄酮、总生物碱及营养素含量的测定[J],食品与发酵工业,2008,34(3):153-156.   出版号:ISSN0253-900X

11. A. Sultan, Satiwaldi, Ablimit, Mukhtar Imerhasan, Bahang, Haji Akber Aisa, K. A. Eshbakova, Flavonoids from Dracoephalum Molorarie L. 7 thInternational Symposium on the Chemistry of Natural Compounds[C], October 16-18,2007, Tashkent Uzbekistan: 208

艾来提·苏里坦,萨提瓦尔地,阿布力米提,穆赫塔尔·伊米尔艾山,巴杭,阿吉阿克拜·艾萨,K. A. Eshbakova, 香青兰中黄酮类化合物的研究[C],第7届国际天然产物化学研讨会,20071016-18日,塔仕干,乌孜别克斯坦:208

10. Ablimit, Ghayrat, Mukhtar Imerhasan, Satewaldi, Yu Jiangliu, Sun Huili, Abdulla Abbas, Study of Flavonoids from Dracoephalum Mololarie L.[J], Chinese Journal of Seience of Food, 2007,28(8):384-386

阿布力米提,艾来提,穆赫塔尔,萨提瓦尔地,余江柳,孙慧丽,阿不都拉·阿巴斯,香青兰中黄酮类化合物的研究[J],食品科学,2007,28 (8): 384-386

9. Mukhtar Imerhasan; Synthesis and Resolution of 2-Methyl-3-disubstitute-tetrahydro-isoxazole Derivatives[J], Chinese Journal of Synthetic Chemistry2007,15(4):430-433

穆赫塔尔·伊米尔艾山, 2-甲基-3-双取代基-4, 5-二氢异噁唑衍生物的合成及其拆分[J]. 合成化学,2007,15 (4): 430-433

8.   Arkin Tursun, Mukhtar Imerhasan, Elnor Ahtamuwa; Synthesis of Tailed Porphyrin H2 [5-Br-PADABPP] and Its Pd 2+ , Ni(bpy) 2+ Complexes[J], Chinese Journal of Synthetic Chemistry2007,15(1): 96-98

艾尔肯·吐尔逊, 穆赫塔尔·伊米尔艾山, 伊丽努尔·艾赫塔木瓦,尾式卟啉H2[ 5-Br-PADAPBPP]及其Pd2 + , Ni(bpy) 2 + 配合物的合成[J]. 合成化学,2007,15 (1): 96-98

7.   Mukhtar Imerhasan,Gulbostan Haydar, Arkin Tursun, Nurmamat Hudabardi1,Ghalipjan Mustakhin; Synthesis of Novel dioxo-pyrrolino[3′,4′-d]isoxazole Derivatives, Chinese Journal of Synthetic Chemistry2007,15(1): 93-95

穆赫塔尔伊米尔艾山, 古丽伯斯坦阿依达尔,艾尔肯吐尔逊, 努尔买买提库达巴尔地,阿里甫江木斯它克,新型二氧代氮杂茂并[3′,4′-d]异噁唑衍生物的合成[J]. 合成化学, 2007,15 (1): 93-95

6.   Volker Jäger, Yaser Bathich, Sunitha Shiva, Feng Li, Mohammad Ibrahim, Marco Henneböhle, Pierre-Yves LeRoy, Mukhtar Imerhasan, 2-Isoxazolinium salts and 3-Isoxazolines: Exploratory Chemistry and uses for the Synthesis of Branched Amino Polyols and Amino Acids[C],2nd International Conference on Heterocyclic Chemistry. University of Rajasthan, Jaipur India, Dec.16-19, 2006: 1-18

5.   Kurban Osman, Mukhtar Imerhasan; Analysis of contents of total flavonoid microelement and fat in Fructus Berberis Vulgaris[J], Journal of Medicine and Pharmacy of Chinese Minorities,2005,11 (5):38-39

库尔班·吾斯曼; 穆赫塔尔·伊米尔艾山. 维吾尔药孜尔克中总黄酮、微量元素及脂肪含量的测定.中国民族医药杂志,2005,11(5):38-39

4.   Gulbostan Haidar, Mukhtar Imerhasan, Setiwaldi Helil; Extractioan of Brick Redness Pigment and Reseach on Its Physical and Chemical Chracter[J], Journal of Xinjiang University, 2005,22(3):303-306

古丽波斯坦·阿依德尔;穆赫塔尔·伊米尔艾山, 萨提瓦尔地赫力力.马林果砖红色素的提取及其热稳定性的研究[J],新疆大学学报,2005,22(3):303-306

3.   W. Frey,  M. Imerhasan, Y. Bathich, V. Jaeger; Crystal structure of (5S,8S)-8-hydroxymethyl-1-methyl-2,7-dioxa-1-aza-spiro[4,4]nonan-6-one[J], Zeitschrieft für Kristallographie—New Crystal Structure(NCS) 2005,220 (6)153-154

2. Kurban Osman, Mukhtar Imerhasan; Determinatioan of Ephedrinne Hydrochloride from Uigur Traditional Medicine Majuni Wuremeili use the Acidity Dyestuff Compares the Color Methods[J], Journal of Kashgar Teachers College(Natural Sciences) , 2004,25(3):55-56

库尔班·吾斯曼; 穆赫塔尔·伊米尔艾山.维吾尔药买居尼喔热孜力中麻黄碱含量的比色法测定.喀什师范学院学报(汉文),2004,25(3):55-56

1.    M. Henneboele, M. Imerhasan,Y. Bathich,V. Jaeger; N-Methyl-Isoxazolinium-Salz: New Building Blocks in the Stereoselective Synthesis of Amino Polyos and Amino[C], 6.IMINIUMSALZ-TAGUNG Stimpfach-Rechenberg, Germany, Sep.15-18,2003: 99-107

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